Highlights • Primordium leader and follower cells need to sense Cxcl12a for efficient migration • Cadherins mediate adhesion between primordium cells • Wild-type cells require Cdh1 to pull attractant-blind neighboring cells • Cadherins and Cxcl12a sensing mediate cell polarity and primordium directionality Summary The directed migration of cells sculpts the embryo, contributes to homeostasis in the adult, and, when dysregulated, underlies many diseases [ , 2 Sonnemann K.J. Bement W.M. Wound...
