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Alison E. John

As seen in: Wiley Online Library, QJM, The Journal of Biological Chemistry
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Articles by Alison E. John

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

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By Alison E. John, Marc A Fernandez-Yague, Yi-Tung Lu
| Wiley Online Library Verified
1 Introduction Far from being passive scaffolds, extracellular matrices (ECMs) participate in mechanically coupled feedback loops with cells. Cells generate traction forces, remodel matrix architecture and composition, and respond to the mechanical information returned by their surroundings. These reciprocal interactions regulate tissue development, organization, homeostasis, repair, and disease progression [1-3].
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P112 Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis

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By Rob Slack, Alison E. John, Ellen Forty, Paul L. Mercer
| QJM Verified
P112 Discovery of a Novel, High Affinity, Small Molecule ?v?6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis Rob Slack, Alison John, Ellen Forty, Paul Mercer, Rebecca Graves, Tao Pun, Giovanni Vitulli, Elaine Gower, Valerie Morrison, Steve Ludbrook, Carmel Nanthakumar, Niall Anderson, Pan Procopiou, John Pritchard, David Budd, David Flint, Susan Pyne, Jane Denyer, John Marshall, Andrew Fisher, Rachel Chambers, Gisli Jenkins, Pauline Lukey, Simon Macdonald, Richard Marshall QJM...
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Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression

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By Amanda L. Tatler, Anthony Habgood, Joanne Porte, Alison E. John, Anastasios Stavrou
| The Journal of Biological Chemistry Verified
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Active TGFβ1 is considered central to the pathogenesis of IPF. A major mechanism of TGFβ1 activation in the lung involves the epithelially restricted αvβ6 integrin. Expression of the αvβ6 integrin is dramatically increased in IPF. How αvβ6 integrin expression is regulated in the pulmonary epithelium is unknown.
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