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Key Points Question Does increased daily water intake prevent cystitis in premenopausal women experiencing recurrent cystitis who drink low volumes of total fluid daily? Findings In this randomized clinical trial of 140 premenopausal women experiencing recurrent cystitis who report drinking less than 1.5 L of total fluid daily, cystitis episodes were significantly less frequent in women who drank more water for 12 months compared with women who maintained their usual fluid intake.
FGF21 Is Induced by Both Fasting and Glucose Challenge ChREBP Is Necessary for Glucose-Mediated Expression and Secretion of Hepatic FGF21 Glucose Stimulation or ChREBP Overexpression Is Not Efficient to Induce FGF21 Expression or Secretion in the Absence of Hepatic PPAR? FGF21 Synergistically Responds to Glucose and a Pharmacological PPAR? Activator in Both Mouse and Human Hepatocytes Hepatocyte PPAR?
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