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Alistair D Falconer on Muck Rack

Alistair D Falconer

As seen in: Science Magazine, BioRxiv
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Articles

Mechanochemical patterning localizes the organizer of a luminal epithelium

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By Zhongping Lai, Shunda Yuan, Alistair D Falconer, Moritz Mercker
| Science Magazine Verified
Abstract The spontaneous emergence of tissue patterns is often attributed to biochemical reaction-diffusion systems. In Hydra tissue regeneration, the formation of a Wnt signaling center exemplifies this process. However, a strictly biochemical mechanism for self-organization in Hydra remains elusive. In this study, we investigated mechanical stimuli and identified a positive feedback loop between Wnt signaling and tissue stretching.
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Mechanochemical Patterning Localizes the Organizer of a Luminal Epithelium

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By Alistair D Falconer, Moritz Mercker, Jaroslav Ferenc, Hajar Sadeghi
| BioRxiv
Abstract The spontaneous emergence of tissue patterns is often attributed to biochemical reaction-diffusion systems. In Hydra tissue regeneration, the formation of a Wnt signaling center serves as a well-known example of such a process. However, despite extensive research, a strictly biochemical mechanism for self-organization in Hydra remains elusive. In this study, we investigated mechanical stimuli and identified a positive feedback loop between Wnt signaling and tissue stretching.
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Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments

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By Robert J. Ju, Kevin Dean, Reto Fiolka, Alistair D Falconer
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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