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Articles by Alistair Ring
121 Five-Year Analysis of Distant Disease-Free Survival (DDFS) Across Key Subgroups From the Phase 3 NATALEE Trial of Ribociclib (RIB) Plus a Nonsteroidal Aromatase Inhibitor (NSAI) in Patients With HR+/HER2− Early Breast Cancer (EBC)
Background Despite improvements in outcomes in patients with hormone receptor–positive early breast cancer, distant recurrence remains a major concern given that there is no cure for metastatic breast cancer. The NATALEE trial has shown invasive disease-free survival (iDFS) and distant disease-free survival (DDFS) benefits with ribociclib plus a nonsteroidal aromatase inhibitor (NSAI) in patients with stage II/III hormone receptor–positive/HER2-negative (HER2–) early breast cancer.
Cost Utility of Geriatric Assessment and Management in Older Adults With Cancer: From Evidence to Implementation
As the population of older adults with cancer grows,1 the oncology community faces the challenge of delivering evidence-based, person-centered, and sustainable care. Geriatric assessment and management (GAM) has long been advocated as a strategy to optimize outcomes by tailoring cancer treatment to the vulnerabilities of diverse aging patient populations.
Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial - British Journal of Cancer
Trial design and participants This thromboxane biosynthesis study was embedded within the randomised Add-Aspirin trial framework. The Add-Aspirin protocol encompasses four individually powered, Phase III, adjuvant studies in four different tumour types, i.e., breast, colorectal, gastro-oesophageal and prostate. Full details of the trial have been published previously [35].
Systemic therapy for older patients with early breast cancer
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA: A Cancer Journal for Clinicians. 2020;70(1):7-30. Derks MGM, Bastiaannet E, Kiderlen M, Hilling DE, Boelens PG, Walsh PM, et al. Variation in treatment and survival of older patients with non-metastatic breast cancer in five European countries: a population-based cohort study from the EURECCA Breast Cancer Group. Br J Cancer. 2018;119(1):121-9. Soto-Perez-de-Celis E. Li D. Yuan Y. Lau Y.M. Hurria A.
Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer
Abstract Background Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study determined if there are fit older patients with high-risk disease who may benefit from chemotherapy. Methods A multicentre, prospective, observational study was performed to determine chemotherapy (±trastuzumab) usage and survival and quality-of-life outcomes in EBC patients aged ≥70 years.
CDK4/6 inhibition in HER2-positive breast cancer
The cyclin-dependent kinase 4 (CDK4) and 6 (CDK6) inhibitors have revolutionised the management of advanced hormone receptor-positive, HER2-negative breast cancer. Palbociclib, ribociclib, and abemaciclib have been approved in combination with endocrine therapy on the basis of consistent improvements in progression-free survival, and emerging improvements in overall survival, in treatment-naive and pretreated advanced breast cancer.
Breast cancer survivorship: key issues and priorities of care
Breast cancer survivorship: key issues and priorities of care Ridhima Iyer, Alistair Ring Br J Gen Pract 2017; 67 (656): 140-141. DOI: 10.3399/bjgp17X689845
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