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Aliza P. Wingo on Muck Rack

Aliza P. Wingo

As seen in: Environmental Health Perspectives, Nature, Genome Medicine, Science Magazine, BioRxiv, Neurology
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Articles

Differential DNA methylation in blood as potential mediator of the association between ambient PM 2.5 and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort

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By Tszshan Ma, Jiaqi Liu, Donghai Liang, Stefanie Ebelt, Kyle Steenland, Allan Levey, James J. Lah, Aliza P. Wingo, Thomas S. Wingo, Anke Hüls
| Nature Verified
Abstract Fine particulate matter (PM2.5) is a known risk factor for Alzheimer’s disease (AD), with emerging evidence showing its effects detectable in the pre-clinical stage through cerebrospinal fluid (CSF) biomarkers of AD.
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Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds - Neuropsychopharmacology

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By Nadine Staples Parker, Elise Koch, Alexey Shadrin, Julian Führer, Guy Hindley, Sara Stinson Verified, Piotr Jaholkowski, Markos Tesfaye, Anders M. Dale, Thomas S. Wingo, Aliza P. Wingo, Oleksandr Frei, Kevin O’Connell, Olav B. Smeland, Ole A. Andreassen
| Nature Verified
Abstract Genetics can inform biologically relevant drug development and repurposing, which may improve patient care. Here, we leverage the genetics of psychiatric disorders to prioritize potential drug targets and compounds. We used the genome-wide association studies of four psychiatric disorders [attention deficit hyperactivity disorder (ADHD), bipolar disorder, depression, and schizophrenia] and genes encoding drug targets.
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Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions - Nature Genetics

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By Aliza P. Wingo, Ananth Shantaraman, Joseph S. Reddy, Mariet Allen, Nilüfer Ertekin-Taner, Michael Epstein, David Cutler, Allan Levey, Nicholas T. Seyfried
| Nature Verified
Abstract To understand shared and ancestry-specific genetic control of brain protein expression and its ramifications for disease, we mapped protein quantitative trait loci (pQTLs) in 1,362 brain proteomes from African American, Hispanic/Latin American and non-Hispanic white donors.
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