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Highlights • Lysosome-associated genes are required in follicle cells for nurse cell death • V-ATPases localize to the plasma membrane of follicle cells to acidify nurse cells • Cathepsin L is released by follicle cells and promotes nurse cell DNA degradation Summary Cell death is a fundamental aspect of development, homeostasis, and disease; yet, our understanding of non-apoptotic forms of cell death is limited.
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