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Allal Challioui on Muck Rack

Allal Challioui

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Articles

Mechanistic multiscale modeling identifies putative natural tri-target candidates of MAO-B, LRRK2 and A₂A for Parkinson’s disease

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By Oussama Khibech, Salma Kadda, Abdessamad Benabbou, Mohamed Bouhrim, Shehdeh Jodeh, Diana Jodeh, Belkheir Hammouti, Allal Challioui
| Nature Verified
Abstract Parkinson’s disease (PD) is a rapidly growing neurodegenerative disorder for which current dopaminergic and device-based therapies remain purely symptomatic and fail to modify disease progression. Addressing the multifactorial biology of PD under stringent blood-brain barrier constraints requires CNS-penetrant small molecules that can simultaneously engage several validated targets.
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