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Allan Lawrie on Muck Rack

Allan Lawrie

Sheffield
As seen in: Nature, Science Magazine, AHA/ASA Journals, European Respiratory Journal, Future Medicine
Imperial College London and BHF Senior Fellow. Research pulmonary hypertension. Views and comments are all my own.
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Articles

Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension

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By Olha Melnyk, Rowena Jones, Leslie Wagner, Eckart De Bie, Nina Deliu, Anthony Y. K. C. Ng, Benjamin J. Dunmore, Stefan Gräf, Christophe Guignabert, Marc Humbert, Laurent Savale, Athénaïs Boucly, Joseph A. Newman, Gary Polwarth, Paul D Upton, Allan Lawrie, Christopher Rhodes, Martin Wilkins, Anna R. Hemnes, Sofía Villar, James West, Mark Toshner, Nicholas W. Morrell, Sarah K. Binmahfooz, Alexander M.K. Rothman
| Science Magazine Verified
Editor’s summary Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Editor’s summary Pulmonary arterial hypertension (PAH) does not have many treatment options, and pulmonary biopsies are unsafe in these patients, so biomarkers of target engagement are needed for clinical trials.
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A blood biomarker to specifically identify idiopathic pulmonary arterial hypertension - Nature Cardiovascular Research

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By Merve Keles, Martin Wilkins, Allan Lawrie
| Nature Verified
Idiopathic pulmonary arterial hypertension is a rare, progressive and life-limiting disease that is difficult to diagnose because of its nonspecific symptoms and reliance on invasive right-heart catheterization for diagnosis. Diagnostic delays contribute to a highly heterogeneous patient population.
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Endoglin as a BMP9 co-receptor in vascular endothelial cells: prodomain displacement and TGFBRII recruitment - Nature Communications

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By Ioannis Kamzolas, Eckart De Bie, Christopher Rhodes, Allan Lawrie, Martin Wilkins, Marie-Jose Goumans, Evangelia Petsalaki, Jason Hong, Jingxu Guo, Karolina Kostrzyńska
| Nature Verified
Abstract Endoglin (ENG) is a single-pass transmembrane protein highly expressed in vascular endothelial cells (ECs), where it plays fundamental roles in EC functions. ENG is implicated in several cardiovascular disorders including hereditary haemorrhagic telangiectasia, pulmonary arterial hypertension (PAH) and preeclampsia. However, molecular mechanisms underlying ENG function are not fully understood.
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