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CRC remains an important public health problem worldwide, and LNM is an important prognostic factor for CRC. LNM in CRC is a multifaceted process involving tumor cell invasion, endocytosis, transport through the lymphatic system, retention in the lymph nodes, extravasation, proliferation, angiogenesis, and interaction with the immune system (Cao et al., 2022; Huang & Chen, 2017; Jiang et al., 2013; Wang et al., 2021; Yan, Su & Qin, 2020).
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