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Allert J Jonker on Muck Rack

Allert J Jonker

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Articles

The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease

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By Allert J Jonker, Marko Popovic, Jochen Walter, Marjolein Bulk
| link.springer.com
Abstract Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance. Previously, we observed an atypical Aβ deposit, referred to as the coarse-grained plaque. In this study, we evaluate the plaque’s association with clinical disease and perform in-depth immunohistochemical and morphological characterization.
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Differential Insular Cortex sub‐regional vulnerability to α‐synuclein pathology in Parkinson's disease and Dementia with Lewy bodies

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By Yasmine Y Fathy, Allert J Jonker, Ellen Oudejans
| Wiley Online Library Verified
The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional, and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and Dementia with Lewy bodies (DLB), it reveals α‐synuclein pathology in advanced stages. The aim of this study is to assess the insular cortex cellular and sub‐regional vulnerability to α‐synuclein pathology in well‐characterized PD and DLB subjects.
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