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Allison Barton

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Precision Antimicrobial Therapy Against Fusobacterium nucleatum Using Bioengineered Probiotics Expressing Guided Antimicrobial Peptides (gAMPs)

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By Ankan Choudhury, Colin Scano, Allison Barton, Christopher M. Kearney
| Wiley Online Library Verified
1 Introduction The oral pathogen, Fusobacterium nucleatum (F. nucleatum), has been identified as a contributor to inflammation, inflammatory bowel diseases and cancer, particularly colorectal cancer (CRC) (Francescone et al. 2014). Several virulence factor proteins, including FomA, FadA, RadD and Fap2, expressed by F. nucleatum, have established connections with host cell invasion, aggregation, biofilm formation and the activation of multiple carcinogenesis (Han et al. 2000; Kaplan et al.
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