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Alper Devrim Özkan on Muck Rack

Alper Devrim Özkan

As seen in: Nature
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Articles

JAK2-driven hERG trafficking reprograms bioelectric states to promote retinoblastoma invasion

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By Serdar Durdağı, Pragati Gupta, Basma Sukkar, Ismail Erol, Berna Dogan, Dennis-Dominik Rosmus, Julian Wolf, Ayse Sahaboglu, Yogesh P Singh, Clemens Lange, Peter Wieghofer, Yagmur Demircan-Yalcin, Alper Devrim Özkan, Shefalee K. Bhavsar, Tatsiana Castor, Zohreh Hosseinzadeh
| Nature Verified
Abstract Retinoblastoma (RB) is the most common intraocular malignancy in children due to inactivation of the RB1 gene, and delayed diagnosis often results in poor outcomes due to its aggressive metastatic potential. Membrane potential (MP) has been implicated in tumor invasion, yet the upstream signaling pathways shaping RB bioelectricity remain unknown.
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