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Alysia Hubbard

As seen in: Nature
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Articles

OXR1 is a dual redox–mitochondrial checkpoint governing osteoclast differentiation and bone loss in an osteoporosis mouse model

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By Xiaojun Chen, Chengyu Zhou, Qiongxiang Lin, Lizhen Li, Zhongxiang Wang, Qiu Dong, Jianbo He, Kavishadhi N Chandrasekaran, Chau Minh Bui, Châu Bùi, Alysia Hubbard, Lei Chen, K. Swaminathan Iyer, Jiandong Yuan, Nathan J. Pavlos, Haibo Jiang, Kai Chen, Xiangyun Jin, Buran Chen, Qunwei Dong
| Nature Verified
Abstract Osteoclasts are mitochondria-rich cells that rely on oxidative phosphorylation to fuel differentiation and bone resorption. Oxidative phosphorylation generates reactive oxygen species (ROS), which support signaling but can also threaten mitochondrial integrity. Oxidation Resistance 1 (OXR1) is a redox-responsive regulator involved in antioxidant defense, but its role in osteoclasts remains unclear.
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Biological contributions to manganese oxides in rock varnish at Murujuga (Western Australia)

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By Ying-Li Wu, John Fairweather, Matthew Campbell, Janet Hergt, Emielda Yusiharni, Aaron Dodd, Xiao Sun, Peta Clode, Jo McDonald, Michael Smirk, Alysia Hubbard, Morten Erik Allentoft
| Nature Verified
Abstract Rock varnish is a ubiquitous Mn-rich coating on exposed rock surfaces in arid environments, yet the mechanisms underlying its formation remain debated. Here, we investigate rock varnish from Murujuga, Western Australia, to assess the role of microbial processes in manganese (Mn) accumulation.
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