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A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation

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By Alisa A Omelchenko, Syed A. Rahman, Alyson Wang, Tracy Tabib, Vinayak V. Viswanadham, Grace J. Yuen, Valentino D’Onofrio, Yijia Chen, Na Sun, Hamid Mattoo, Swapnil Keshari, Gonzalo Salgado Verified, Maribel Soto-Nava, Santiago Ávila-Ríos, Susan P. Ribeiro, Mark J. Shlomchik, Amanda C. Poholek, Shiv Pillai, Rebecca A. Elsner, Vinay S. Mahajan, Jishnu Das, Chinmay V. Gadiraju, Dafne Díaz-Rivera, Sudhir P. Kasturi
| Nature Verified
Abstract Characterizing multi-scale processes underlying immune-state progression is critical for defining their function. This becomes pertinent for functionally diverse and plastic immune cells, such as T follicular helper (Tfh) cells. Here, we adopt a multi-scale network-systems approach that incorporates both regulatory and protein-protein interactions.
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