Amal Abd Elkader on Muck Rack

Amal Abd Elkader

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Articles

Activity-dependent COX-2 proteolysis generates a catalytically inactive fragment that affects aerobic respiration and proliferation

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By Liat Hagit Hartal-Benishay, Sharon Tal, Amal Abd Elkader, Omar Ehsainieh
| biorxiv.org
Abstract Cyclooxygenase-2 (COX-2) catalyzes arachidonic acid (AA) into PGH2, the single source of all prostaglandins (PGs), ligands that activate multiple inflammatory pathways. AA catalysis quickly results in suicide inactivation, rendering the enzyme catalytically inactive. We show that the catalytic activity also leads to controlled cleavage of COX-2, an event that is differentially regulated by fatty acids, and blocked by COX inhibitors. We also observe COX-2 cleavage in human colon tumors.
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Activity-dependent COX-2 proteolysis generates a catalytically inactive fragment that affects aerobic respiration

|
By Sharon Tal, Liat Hagit Hartal-Benishay, Amal Abd Elkader, Omar Ehsainieh
| biorxiv.org
Abstract Cyclooxygenase-2 (COX-2) catalyzes arachidonic acid (AA) into PGH2, the single source of all prostaglandins (PGs), ligands that activate multiple inflammatory pathways. AA catalysis by COX-2 quickly leads to suicide inactivation, rendering the enzyme catalytically inactive. We show that the catalytic activity is followed by controlled cleavage of COX-2, an event that is differentially regulated by fatty acids and blocked by COX inhibitors.
Open in Who Shared Issue with article?
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