CLINICAL GUIDE COUNSELING POINTS These studies demonstrate that as estimates of increased risk, albeit modest, are becoming more precise for these moderate-penetrance genes, guidance on how to discuss and appropriately select patients for RRSO is critical to avoid unnecessary procedures and associated morbidity, particularly in premenopausal women. Using our clinical guide, individuals with pathogenic variants in genes to the right of the dotted line are thought to benefit from RRSO.
