Amanda Yin Schioldborg on Muck Rack

Amanda Yin Schioldborg

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Articles

Patient-matched transcriptomics of in vivo and in vitro colonic epithelium substantiate organoids as a translational model for ulcerative colitis

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By Arun R Sridhar, Lusie Frostvoll Kuraas, Siri Sæterstad, Amanda Yin Schioldborg, Atle Van Beelen Granlund, Arne Sandvik, Ann Elisabet Østvik, Ingunn Bakke, Torunn Bruland
| Nature Verified
Abstract Ulcerative colitis (UC) is characterized by cytokine-driven inflammation and barrier disruption in the colon, making epithelial dysfunction central to disease pathology. Intestinal epithelial organoids (IEOs) preserve donor-specific genetics and architecture, offering a promising model, but their ability to replicate patient-specific epithelial inflammation remains undetermined.
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