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Amel Ben Saad

As seen in: BioRxiv, Cell Metabolism
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Articles

Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease

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By Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-ur Rahman
| embopress.org
Introduction Chronic liver injury promotes sustained inflammation, leading to liver fibrosis, which can progress to cirrhosis (Loomba et al, 2021), a major cause of morbidity and mortality worldwide (Sepanlou et al, 2020). Metabolic dysfunction-associated steatotic liver disease (MASLD, also known as non-alcoholic fatty liver disease or NAFLD) (Rinella et al, 2023) is tightly linked to obesity and metabolic syndrome (Anstee et al, 2019).
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Single cell transcriptomic landscapes of human liver organoids stratify models of non-alcoholic fatty liver disease

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By Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-ur Rahman
| BioRxiv
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Singletrome: A method to analyze and enhance the transcriptome with long noncoding RNAs for single cell analysis

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By Raza Rahman, Iftikhar Ahmad, Robert SJ Sparks, Amel Ben Saad
| BioRxiv
New Results doi: https://doi.org/10.1101/2022.10.31.514182 Abstract Single cell RNA sequencing (scRNA-seq) has revolutionized the study of gene expression in individual cell types from heterogeneous tissue. To date, scRNA-seq studies have focused primarily on expression of protein-coding genes, as the functions of these genes are more broadly understood and more readily linked to phenotype.
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