Amelia Pearson on Muck Rack

Amelia Pearson

Pittsburgh
As seen in: WV News, Bayside Leader, The Melbourne City News, City Messenger News, City North Messenger, Guardian Messenger, Southern Times Messenger, The Exponent Telegram, Geelong Advertiser, Soundscape Magazine
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Articles

Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia

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By Amelia Pearson, Lev Yampolsky
| biorxiv.org
Abstract NAD+ homeostasis is an important determinant of lifespan and may be a key mechanism of caloric restriction (CR) expansion of lifespan. Ketone bodies such as beta-hydroxybutyrate (BHB) that regulate NAD+ abundance and NAD+ precursors such nicotinamide mononucleotide (NMN), as are known to extend life in experimental animals and ameliorate age-related conditions in humans.
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Ketone body b-Hydroxybutyrate does not extend lifespan, but upregulates fecundity in food-limited Daphnia, with a transgenerational effect

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By Amelia Pearson, Lev Yampolsky, Shymal C. Bharda
| biorxiv.org
Abstract Ketone bodies accumulate on ketogenic diets and are known to have numerous beneficial health and longevity effects. Here we investigate the effects of exposure to environmental b-hydroxybutyrate (BHB), a ketone body, on longevity and fecundity of a model organism Daphnia magna, a plankton crustacean, maintained at limited food availability.
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Post-senescence reproductive rebound in Daphnia does not accelerate mortality and is associated with reversal of age-related transcriptional changes in lipid and protein metabolism

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By Ishaan Dua, Amelia Pearson, Rachael L. Lowman, Lev Yampolsky
| biorxiv.org
Abstract A long-lived species of zooplankton microcrustaceans, Daphnia magna, sometimes exhibits late-life rebound of reproduction, briefly reversing reproductive senescence. Such events are often interpreted as terminal investment in anticipation of imminent mortality. We demonstrate that such post-senescence reproductive events (PSREs) neither cause not anticipate increased mortality. We analyze an RNAseq experiment comparing young, old reproductively senescent, and old PSRE Daphnia females.
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