Amelie Alfert

M. C.Heider, A.Alfert, M.Hotfilder, B.Burkardt, and M.te Vrugt, “Two Faces of NOTCH1 in Childhood Lymphoblastic T-Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations.” Pediatric Blood & Cancer (2026): e70380. https://doi.org/10.1002/1545-5017.70380 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Abstract T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL) originate from thymic T-cell precursors, with ongoing debate on whether they are variants of the same disease or distinct entities. For 211 patients, including pediatric and adult T-ALL and T-LBL cases, targeted next-generation sequencing and SNP-arrays were performed, and single-nucleotide variants, indels and copy-number variants (CNVs) were analyzed.