Amilia Nusbaum

1 Introduction Osteoclasts are specialized multinucleated cells derived from the monocyte/macrophage lineage of myeloid cells upon exposure to macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) (Boyce et al. 2009; Kodama and Kaito 2020). They are responsible for physiological bone remodeling and pathological alveolar bone resorption in periodontitis lesions, which is one of the major diseases affecting the oral cavity (AlQranei and Chellaiah 2020).

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessCommunication by Nora Ludwig 1,†, Isaac S. Demaree 1,†, Chiaki Yamada 2,3, Amilia Nusbaum 2, Frank C. Nichols 4, Fletcher A. White 5,6,7, Alexandru Movila 2,3,* and Alexander G.