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Amorette Barber on Muck Rack

Amorette Barber

As seen in: Color Research & Application
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Articles

Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 receptor as an immunotherapy for lymphoma

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By Adam Lynch, William Hawk, Emily Nylen, Sean Ober, Pierre Autin, Amorette Barber
| Color Research & Application Verified
Adoptive transfer of T cells is a promising cancer therapy and expression of chimeric antigen receptors can enhance tumor recognition and T cell effector functions. The PD1 receptor is a prospective target for a chimeric antigen receptor because PD1 ligands are expressed on many cancer types, including lymphoma. Therefore, we developed a murine chimeric PD1 receptor (chPD1) consisting of the PD1 extracellular domain fused to the cytoplasmic domain of CD3 zeta.
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