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Amuliya Kashyap on Muck Rack

Amuliya Kashyap

As seen in: BioRxiv
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Articles

Drug resistance through ribosome splitting and rRNA disordering in mycobacteria

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By Soneya Majumdar, Ravi K. Koripella, Manjuli R Sharma, Amuliya Kashyap
| BioRxiv
Abstract HflX is known to rescue stalled ribosomes and is implicated in antibiotic resistance in several bacteria. Here we present several high-resolution cryo-EM structures of mycobacterial HflX in complex with the ribosome and its 50S subunit, with and without antibiotics. These structures reveal a distinct mechanism for HflX-mediated ribosome splitting and antibiotic resistance in mycobacteria.
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