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Articles by Amy V Paschall
A regulatory B cell subpopulation expressing CD301b lectin promotes breast cancer growth
Abstract Tumor-associated carbohydrate antigens (TACAs) can promote tumor growth by regulating the anti-tumor immune response. The accumulation of immune suppressor cells within the tumor in response to TACAs suggests a critical pathway to suppress immune targeting of the tumor. Employing murine breast cancer models, we isolated a regulatory B cell subpopulation in the breast tumor microenvironment that displays an immune suppressive phenotype through its Tn TACA-binding lectin, CD301b.
Harnessing galactose oxidase in the development of a chemoenzymatic platform for glycoconjugate vaccine design
In the preparation of commercial conjugate vaccines, capsular polysaccharides (CPSs) must undergo chemical modification to generate the reactive groups necessary for covalent attachment to a protein carrier. One of the most common approaches employed for this derivatization is sodium periodate (NaIO4) oxidation of vicinal diols found within CPS structures.
Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection
Microbial Immunity and Vaccines | Spotlight Jiachen Huang, Aaron D. Gingerich, Fredejah Royer, Amy V. Paschall, Alma Pena-Briseno, Fikri Y. Avci, Jarrod J. Mousa Liise-anne Pirofski, Editor DOI: 10.1128/IAI.00747-20 ABSTRACT Streptococcus pneumoniae remains a leading cause of bacterial pneumonia despite the widespread use of vaccines.
Glycosyltransferases within the psrP Locus Facilitate Pneumococcal Virulence
Research Article Dustin R. Middleton, Javid Aceil, Seema Mustafa, Amy V. Paschall, Fikri Y. Avci Laurie E. Comstock, Editor DOI: 10.1128/JB.00389-20 ABSTRACT The pneumococcal serine-rich repeat protein (PsrP) is a high-molecular-weight, glycosylated adhesin that promotes the attachment of Streptococcus pneumoniae to host cells.
Glycosyltransferases within the psrP Locus Facilitate Pneumococcal Virulence
Research Article Dustin R. Middleton, Javid Aceil, Seema Mustafa, Amy V. Paschall, Fikri Y. Avci DOI: 10.1128/JB.00389-20 ABSTRACT The Pneumococcal Serine-Rich Repeat Protein (PsrP) is a high-molecular weight, glycosylated adhesin that promotes the attachment of Streptococcus pneumoniae (Spn) to host cells. PsrP, its associated glycosyltransferases, and dedicated secretion machinery, are encoded in a 37 kb genomic island that is present in many invasive clinical isolates of Spn.
Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells | Cancer Research
Tumor Biology and Immunology Alyssa D. Smith, Chunwan Lu, Daniela Payne, Amy V. Paschall, John D. Klement, Priscilla S. Redd, Mohammed L. Ibrahim, Dafeng Yang, Qimei Han, Zhuoqi Liu, Huidong Shi, Thomas J. Hartney, Asha Nayak-Kapoor and Kebin Liu DOI: 10.1158/0008-5472.CAN-19-3670 Published August 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
Autocrine IL6-mediated activation of the STAT3-DNMT axis silences the TNFα-RIP1 necroptosis pathway to sustain survival and accumulation of myeloid-derived suppressor cells
Research Article Alyssa D. Smith, Chunwan Lu, Daniela Payne, Amy V. Paschall, John D. Klement, Priscilla S. Redd, Mohammed L. Ibrahim, Dafeng Yang, Qimei Han, Zhuoqi Liu, Huidong Shi, Thomas J. Hartney, Asha Nayak-Kapoor and Kebin Liu DOI: 10.1158/0008-5472.CAN-19-3670 Abstract Although accumulation of myeloid-derived suppressor cells (MDSC) is a hallmark of cancer, the underlying mechanism of this accumulation within the tumor microenvironment remains incompletely understood.
An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion
J Clin Invest. 2018 Dec 3; 128(12): 5549–5560. John D. Klement,1,2,3 Amy V. Paschall,1,2,3 Priscilla S. Redd,1,2,3 Mohammed L. Ibrahim,1,2 Chunwan Lu,1,2,3 Dafeng Yang,1,2,3 Esteban Celis,2 Scott I. Abrams,4 Keiko Ozato,5 and Kebin Liu1,2,3 John D. Klement 1Department of Biochemistry and Molecular Biology, and 2Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USA. 3Charlie Norwood VA Medical Center, Augusta, Georgia, USA. Amy V.
Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense
Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense
Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense
Despite a century of investigation, Streptococcus pneumoniae remains a major human pathogen, causing a number of diseases, such as pneumonia, meningitis, and otitis media. Like many encapsulated pathogens, the capsular polysaccharide (CPS) of S. pneumoniae is a critical component for colonization and virulence in mammalian hosts. This study aimed to evaluate the protective role of a glycoside hydrolase, Pn3Pase, targeting the CPS of type 3 S. pneumoniae, which is one of the most virulent serotypes.
T Cell-Mediated Humoral Immune Responses to Type 3 Capsular Polysaccharide of Streptococcus pneumoniae
T Cell–Mediated Humoral Immune Responses to Type 3 Capsular Polysaccharide of Streptococcus pneumoniae Dustin R. Middleton, Lina Sun, Amy V. Paschall, Fikri Y. Avci The Journal of Immunology July 15, 2017, 199 (2) 598-603; DOI: 10.4049/jimmunol.1700026
T Cell-Mediated Humoral Immune Responses to Type 3 Capsular Polysaccharide of Streptococcus pneumoniae
T Cell–Mediated Humoral Immune Responses to Type 3 Capsular Polysaccharide of Streptococcus pneumoniae Dustin R. Middleton, Lina Sun, Amy V. Paschall, Fikri Y. Avci The Journal of Immunology May 31, 2017, 1700026; DOI: 10.4049/jimmunol.1700026
NF-κB acts as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression.
Radiation is a local treatment for many types of solid cancers. About two thirds of cancer patients require radiation during the course of their disease treatment. Radiation modulates both tumor cells and immune cells in the tumor microenvironment to exert anti-tumor activity, but the molecular connection between tumor cells and immune cells that mediates radiation-exerted tumor suppression activity is largely unknown.
IRF8 represses GM-CSF expression in tumor cells to mediate myeloid-derived suppressor cell differentiation.
Myeloid-derived suppressive cells (MDSCs) are immature myeloid cells that are induced by inflammatory mediators. Massive accumulation of MDSCs is a hallmark of cancer in mice and human patients. Proinflammatory factors are believed to induce MDSC differentiation. In an early study, we showed that T cell-produced GM-CSF, a proinflammatory cytokine, induces MDSC accumulation under physiological conditions. We further determined that IRF8 represses MDSC accumulation in vivo.
Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes
Cytotoxic T Lymphocytes (CTLs) are the major effectors of the host cancer immune surveillance. FasL-induced cytotoxicity is one of the two effector mechanisms that CTLs use to kill tumor cells. Fas is the physiological ligand of FasL and its expression and function is often deregulated in cancer cells. Ceramide is a sphingolipid metabolite that mediates Fas function.
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