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Articles by An Hendrix
Chemokine and opioid peptide scavenging through constitutive and ligand-induced release of ACKR3-bearing extracellular vesicles
Abstract Atypical chemokine receptors (ACKRs) are non-signaling GPCRs that regulate ligand availability, with ACKR3 functioning as a dual scavenger of chemokines and opioid peptides. Here, we demonstrate that following ligand stimulation, besides the canonical internalization, ACKR3 is released on extracellular vesicles (EVs). ACKR3 was also found on EVs released under basal conditions, although to a lesser extent.
Exosomal export of activated CASPASE-8 is linked to the prevention of TNF-induced cytotoxicity
Abstract Tumor Necrosis Factor (TNF) is a key pro-inflammatory cytokine whose sensing by TNFR1 triggers gene activation or cell death induction. While TNF cytotoxicity can be beneficial during infections by supporting effective immune responses, its chronic or excessive induction is harmful and promotes inflammatory pathologies. Protective brakes, known as cell death checkpoints, normally repress TNF cytotoxicity and therefore constitute crucial safeguards against these diseases.
Integrated single-cell transcriptomic, proteomic, and tissue-level analysis defines cancer-associated fibroblast programs in pseudomyxoma peritonei
Abstract Pseudomyxoma peritonei (PMP) is an ultra-rare mucinous neoplasm with extensive stromal remodeling, yet the role of cancer-associated fibroblasts (CAFs) remains poorly defined. A PMP-derived CAF culture was established and characterized through multiple omics and phenotypic assays.
Extracellular vesicles: Whisperers of tumor immune evasion
Get full text access Log in, subscribe or purchase for full access. References 1. Hendrix, A. ∙ Lippens, L. ∙ Pinheiro, C. ... Extracellular vesicle analysis Nat. Rev. Methods Primers. 2023; 3:56 2. Patras, L. ∙ Shaashua, L. ∙ Matei, I. ... Immune determinants of the pre-metastatic niche Cancer Cell. 2023; 41:546-572 3. Chen, G. ∙ Huang, A.C. ∙ Zhang, W. ... Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response Nature. 2018; 560:382-386 4. Muller, L. ∙ Simms, P. ∙ Hong, C.S. ...
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids - Nature Protocols
Abstract Spheroids are reaggregated multicellular three-dimensional structures generated from cells or cell cultures of healthy as well as pathological tissue. Basic and translational spheroid application across academia and industry have led to the development of multiple setups and analysis methods, which mostly lack the modularity to maximally phenotype spheroids.
Extracellular vesicle analysis - Nature Reviews Methods Primers
Abstract Cells release small, phospholipid membrane-enclosed particles, collectively referred to as extracellular vesicles (EVs), into their surroundings to enable intercellular communication. EVs have numerous functions in physiological and pathophysiological processes and show considerable promise for diagnostic and therapeutic applications.
Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells
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Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables
Abstract The diagnostic and therapeutic use of extracellular vesicles (EV) is under intense investigation and may lead to societal benefits. Reference materials are an invaluable resource for developing, improving and assessing the performance of regulated EV applications and for quantitative and objective data interpretation. We have engineered recombinant EV (rEV) as a biological reference material.
Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization
Abstract Gram-negative and Gram-positive bacteria release a variety of membrane vesicles through different formation routes. Knowledge of the structure, molecular cargo and function of bacterial extracellular vesicles (BEVs) is primarily obtained from bacteria cultured in laboratory conditions.
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