Ana Sofia Alberto-Silva on Muck Rack

Ana Sofia Alberto-Silva

As seen in: Wiley Online Library
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Articles

Bioisosteric analogs of MDMA: Improving the pharmacological profile?

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By Ana Sofia Alberto-Silva, Selina Hemmer, Hailey A. Bock, Kenneth Scott
| Wiley Online Library Verified
BRET bioluminescence resonance energy transfer CLint intrinsic clearance CLint,micr microsomal intrinsic clearance CYP cytochrome P450 DA dopamine DAT dopamine transporter DDIs drug–drug interactions DFIs drug-food interactions EC50 half-maximal effective concentration E MAX maximum effect FMO3 flavin-containing monooxygenase 3 HEK293 cells human embryonic kidney 293 cells IC50 half-maximal inhibitory concentration LC-HRMS liquid chromatography-high resolution mass spectrometry MDA...
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Bioisosteric analogs of MDMA with improved pharmacological profile

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By Selina Hemmer, Hailey A. Bock, Kenneth Scott, Ana Sofia Alberto-Silva
| biorxiv.org
Abstract 3,4-Methylenedioxymethamphetamine (MDMA, - ecstasy - is re-emerging in clinical settings as a candidate for the treatment of specific psychiatric disorders (e.g. post-traumatic stress disorder) in combination with psychotherapy. MDMA is a psychoactive drug, typically regarded as an empathogen or entactogen, which leads to transporter-mediated monoamine release.
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