Analia Bortolozzi on Muck Rack

Analia Bortolozzi

As seen in: Nature, MDPI, Pharmacological Reviews
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Articles

Peripheral miRNA profiling identifies therapy-specific biological trajectories in the treatment of cognitive dysfunction in depression: an exploratory mechanistic study

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By Lluis Miquel-Rio, Verónica Paz, Leonor P. Gawron, Dolors Puigdemont, Carlo Alemany, Narcis Cardoner, Javier de Diego-Adeliño, Analia Bortolozzi, Maria J Portella, Muriel Vicent-Gil, Judith Jericó-Escolar, Júlia Carrasco-Hernández, Miriam Jubero, Esther Ruiz-Bronchal, Javi Vera
| Nature Verified
Abstract Cognitive dysfunction in major depressive disorder (MDD) often persists despite standard treatment. Integral cognitive remediation (INCREM) shows clinical efficacy, yet its molecular drivers remain poorly understood compared to supportive interventions like psychoeducation (PSYCHOED). In this exploratory study, we investigated whether circulating microRNAs (miRNAs) reflect the distinct biological trajectories of these interventions.
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Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related neurodegenerative deficits - Nature Communications

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By Ariadna Laguna, Nuria Penuelas, Marta González-Sepúlveda, Sébastien Arthaud, Joan Compte, Lluis Miquel-Rio, Thais Cuadros, Jordi Romero-Giménez, Lydia Giménez-Llort, Patrice Fort Verified, Analia Bortolozzi, Camille Guillard-Sirieix, Marina Lorente-Picón, Annabelle Parent
| Nature Verified
Abstract One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neurons that synthesize catecholamines. Neurons reaching the highest neuromelanin levels preferentially degenerate in Parkinson’s, Alzheimer’s and apparently healthy aging individuals.
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