Anand Kumar Bachhawat

Abstract Gamma-Glu dipeptides are ubiquitous in nature, and yet their metabolism and transport are poorly understood. Here we investigate this using the dipeptide gamma-Glu-met in Saccharomyces cerevisiae. gamma-Glu-met was efficiently utilized by S. cerevisiae and its degradation was dependent on both the glutathione degrading cytosolic Dug2p/Dug3p complex, and the vacuolar Ecm38p.

Abstract The cytosolic glutathione-degrading enzyme, ChaC1, is highly upregulated in several cancers, with the upregulation correlating to poor prognosis. The ability to inhibit ChaC1 thus becomes important in pathophysiological situations where elevated glutathione levels would be beneficial. As no inhibitors of ChaC1 are known, in this study we have focussed on this goal. We have initially taken a computational approach where a systemic structure-based virtual screening was performed.

Correction to: Scientific Reports https://doi.org/10.1038/s41598-018-21483-x, published online 21 February 2018 This Article contained errors. As a result of a figure assembly error, in Figure 5b subpanel showing samples vps1Δ through vaps8Δ was duplicated for vps25Δ through vps31Δ and vps53Δ through vps63Δ, for methionine treated samples. This same methionine sample was correctly shown in the Supplementary Information File.