Anantha Ram Nookala on Muck Rack

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Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

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By Anantha Ram Nookala, Janey Ronxhi, Josiah Sliz
| biorxiv.org
Results A Proximal Tubule Kidney-Chip was fabricated to create a micro-engineered environment that recapitulates the proximal tubule section of the kidney. The chip was comprised of two fluidically independent top and bottom channels, separated by a porous polydimethylsiloxane (PDMS) membrane (7 μm pore diameter, ∼3% porosity) coated with ECM (Matrigel and collagen IV) (Figure 1A).
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