Anastassios D Giannou on Muck Rack

Anastassios D Giannou

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Articles

Geminin ablation in vivo enhances tumorigenesis through increased genomic instability

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By Sofia Nikou, Spyridon Champeris Tsaniras, Maria Villiou, Anastassios D Giannou
| Arthritis & Rheumatology Verified
Geminin, a DNA replication licensing inhibitor, ensures faithful DNA replication in vertebrates. Several studies have shown that Geminin depletion in vitro results in rereplication and DNA damage, while increased expression of Geminin has been observed in human cancers. However, conditional inactivation of Geminin during embryogenesis has not revealed any detectable DNA replication defects.
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