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Anaya Y. Clarke on Muck Rack

Anaya Y. Clarke

As seen in: Nature
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Articles

Early induction of the Rho-GEF ECT2 drives MEK/ERK oncogenic signaling in pancreatic ductal adenocarcinoma

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By Ryan Argo, Alicia Martinez, Murli Krishna, Peter Storz, Nicole Murray, Verline Justilien, Dania Al-Qasrawi, Nayya N. Murray, Prita Pandya, Anaya Y. Clarke, Kayla C. Winter
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers because it is typically detected at an advanced stage, progresses rapidly, and resists current therapies. Consequently, early diagnostic biomarkers and novel therapeutic targets are urgently needed. Epithelial Cell Transforming Sequence 2 (ECT2) is a Rho family guanine nucleotide exchange factor that was originally identified as an oncoprotein and later shown to regulate cytokinesis.
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