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Articles by Anders Sundström
High Risk of Metabolic Side Effects Among New Paediatric Antipsychotic Users in Sweden—A Register-Based Study
1 Introduction Antipsychotics are of great importance for the treatment of serious psychiatric conditions. Few antipsychotics are approved for use in children and adolescents by the European Medicines Agency. Risperidone is approved for short-term treatment of conduct disorders from the age of 5 years in children with intellectual disability [1].
Förskrivning av neuroleptika till barn och ungdomar ökar
Neuroleptika och litium, som en del i ett multimodalt behandlingsprogram, har stor betydelse för behandling av allvarliga psykiatriska tillstånd hos barn och ungdomar [1]. Neuroleptika kan delas in i äldre neuroleptika (första generationens antipsykotika), exempelvis haloperidol, klozapin och levomepromazin, och nyare neuroleptika (andra generationens antipsykotika), exempelvis aripiprazol, kvetiapin, olanzapin och risperidon. Vissa neuroleptika är godkända för behandling av barn.
Exempel på metod för studie av följsamhet till kontraindikationer
The daily regulatory work with pharmacovigilance includes requirements of risk minimisation measures (RMM). However, when it comes to evaluating the efficacy of RMM, methodological issues have been raised regarding commonly used surveys, and the updated Guideline on good pharmacovigilance practices, Module XVI Addendum II, proposes using mixed methods when RMM outcome is evaluated.
Förgiftning orsakad av förskrivna läkemedel vanlig vid suicid
Årligen avlider nästan tusen personer till följd av läkemedels– och narkotikaförgiftningar i Sverige, varav cirka 45 procent bedöms vara oavsiktliga förgiftningar (ofta benämnt överdos), 30 procent suicid och 25 procent förgiftningar med oklar avsikt [1]. Förgiftning är det vanligaste tillvägagångssättet vid suicid bland kvinnor och står för cirka 40 procent av alla suicid. Bland män utgör förgiftningar 15 procent av suicid och är det näst vanligaste tillvägagångssättet [2].
A Phenotype-Driven Multi-Omic Atlas of Glioblastoma Invasion
Abstract Glioblastoma (GBM) is a highly invasive and heterogeneous brain tumor, where distinct patterns of growth and invasion critically influence disease progression and therapy response. However, the molecular drivers of these phenotypes remain poorly understood. Here, we present the HGCC Phenobank, a next-generation atlas of 76 patient-derived GBM cases engrafted in mice, integrating histopathology, transcriptomics, epigenomics, and proteomics.
Shoulder pain in badminton players and wrestlers
Ayuda Buscar en la ayuda Buscar en la ayuda Shoulder pain in badminton players and wrestlers Sundström, Anders [1] ; Tärnklev, Conny [1] ; Fahlström, Martin [1] [1] Umeå University Localización: International Journal of Racket Sports Science, ISSN-e 2695-4508, Vol. 6, Nº.
BERT based natural language processing for triage of adverse drug reaction reports shows close to human-level performance
Discussion In this study, we show that transformer-based language models can provide close to human-level performance to the task of triaging reports of suspected ADRs. Given the increasing number of reports globally and the need for preparedness for future surges in the number of reports–e.g., in relation to urgent public health interventions–we believe our results support implementation of AI in the field of regulatory pharmacovigilance, augmenting human assessors by providing automated...
Identification of risk factors for adverse drug reactions in a pharmacovigilance database
Key Points We developed a new method for the identification of potential risk factors for adverse drug reactions in a pharmacovigilance database. We used bleeding associated with direct oral anticoagulants (DOACs)-rivaroxaban, apixaban, edoxaban, and dabigatran-as a test model. We identified 13 risk factors of which 11 were previously known. Previously unknown potential risk factors were dementia and atrial fibrillation.
Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study
Research Association between...
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
Highlights • Human iPSC-derived or primary neuroepithelial stem cells can be transformed by MYCN • MYCN drives infant SHH medulloblastoma with clinically relevant features • Epigenetically regulated Oct4 promotes mTOR hyperactivation in infant SHH tumors • mTOR inhibition efficiently targets metastatic SHH medulloblastoma models and PDXs Summary Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development.
Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity - Niklasson - - The Journal of Pathology - Wiley Online Library
Original Paper Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity Bo Segerman Corresponding Author E-mail address: bo.segerman@igp.uu.se Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, SE‐751 85 Uppsala, Sweden National Veterinary Institute, SE‐750 07 Uppsala, Sweden Correspondence to: Anna Segerman (E‐mail: anna.segerman@igp.uu.se, +46‐18‐6114209) or Bo...
LGR5 promotes tumorigenicity and invasion of glioblastoma stem‐like cells and is a potential therapeutic target for a subset of glioblastoma patients
Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor which lacks efficient treatment and predictive biomarkers. Expression of the epithelial stem cell marker Leucine‐rich repeat‐containing G‐protein coupled receptor 5 (LGR5) has been described in GBM but its functional role has not been conclusively elucidated. Here we have investigated the role of LGR5 in a large repository of patient‐derived GBM stem cell (GSC) cultures.
Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study
Research Association of suicide...
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