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Articles by Andre Matos
Cancer is embedded in a whole-body neural regulatory network
Abstract REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Abstract Solid tumors develop in local microenvironments that are embedded in a whole-body neural regulatory network. By translating host physiology into tumor biology across acute, cumulative, and structural timescales, the body’s neural regulatory network influences metastatic risk and treatment response, identifying opportunities for therapeutic intervention.
The neuroscience of childhood brain cancers
Abstract REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Abstract Nervous system activity drives both normal neurodevelopment and childhood brain cancers through paracrine and synaptic signaling. In childhood gliomas, cancer cells integrate structurally and electrically into neural networks, and neuron-cancer interactions are strongly growth-promoting.
Neural architecture as cancer’s safe harbor
Abstract REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Abstract Targeting peripheral nerves improves antitumor immunity despite overlapping molecular expression in neurons and tumor stroma. This advantage may be due to preexisting innervation establishing spatially restricted signaling zones that favor immune suppression early in transformation.
Cancer neuroscience: Mechanisms to medicine
Abstract INTRODUCTION CNS MECHANISMS PNS MECHANISMS: CIRCUITS, SCAFFOLDS, AND METABOLIC REPROGRAMMING CURRENT TREATMENTS TARGETING THESE VULNERABILITIES CONCLUSION Acknowledgments REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The nervous system is now recognized as an enabling hallmark of cancer biology.
Glioblastoma: Overcoming fundamental biological and delivery barriers to therapy
Abstract INTRODUCTION CURRENT STANDARD OF CARE EMERGING THERAPEUTIC STRATEGIES INNOVATIVE CLINICAL TRIAL DESIGN AND TRANSLATIONAL STRATEGY IN GBM COMBINATION AND SEQUENCING APPROACHES CONCLUSION AND OUTLOOK Acknowledgments REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Glioblastoma remains the most aggressive primary malignant brain tumor in adults, with survival largely unchanged despite advances in molecular...
Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Oral squamous cell carcinoma (OSCC) is often associated with pain and perineural invasion, yet the underlying mechanism and role in progression are unknown. Here, Martel-Matos et al. investigated how cancer-induced injury drives neuropathic pain through adrenergic sensitivity and tumor-associated sensory neurons.
Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing postoperative blood-brain barrier disruption
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Standard of care for glioblastoma (GBM) includes maximal safe resection followed by radiotherapy and temozolomide; however, recurrence often occurs, and further treatment is often hindered by the blood-brain barrier (BBB). Here, Fernandes et al.
Targeting neurotumoral signaling networks in cancer
REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Related Research Articles Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing postoperative blood-brain barrier disruption Science Translational Medicine29 Jul 2026 Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma Science Translational Medicine29 Jul 2026 Related...
Robust CD4 + CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma
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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary The underlying cause of nonimmune effector cell–associated neurotoxicity syndrome neurotoxicities (NINTs) in patients treated with the chimeric antigen receptor T cell (CAR T cell) therapy ciltacabtagene autoleucel is poorly understood. Here, Jurgens et al.
By Lorena F Fernandes, Andre Matos, Eric Jurgens, Sneha Mitra, Kevin Herrera, David Nemirovsky, Andriy Derkach, Kinga Hosszu, Devin McAvoy, Ross Firestone, Sridevi Rajeeve, Alexander M. Lesokhin, Neha Korde, Carlyn Tan, Hamza Hashmi, Hani Hassoun, Kylee H. Maclachlan, Urvi A. Shah, Malin Hultcrantz, Maximilian Merz, Francesco Maura, Sergio A. Giralt, Gunjan L. Shah, Heather Landau, Brenden Bready
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Tactical constructivism and the enlargement of the European Union: Türkiye as a strategic partner and normative challenge in the fields of migration and energy
English This article analyses the relationship between the European Union and Türkiye in the context of Enlargement Policy, using migration and energy as case studies. The research sought to explore how normative dynamics between the European Union and Türkiye develop in contexts of asymmetric cooperation, using the theoretical framework of tactical constructivism to understand how norms are strategically mobilised.
Editorial 39.1: Rethinking the Geopolitical Shifts and Security in the New Millennium
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Water | Free Full-Text | Patterns and Predictors of Phytoplankton Assemblage Structure in a Coastal Lagoon: Species-Specific Analysis Needed to Disentangle Anthropogenic Pressures from Ocean Processes
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O tudo ou nada para a Turquia e uns pozinhos para o resto do mundo
No dia 14 de maio, não se discute apenas o futuro imediato de cerca de 80 milhões de turcos; os resultados destas eleições terão um impacto no sistema regional euro-asiático que não será de desconsiderar.
O tudo ou nada para a Turquia e uns pozinhos para o resto do mundo
No dia 14 de maio, não se discute apenas o futuro imediato de cerca de 80 milhões de turcos; os resultados destas eleições terão um impacto no sistema regional euro-asiático que não será de desconsiderar.
Evolução da cirurgia: dos cirurgiões barbeiros ao robô
Antigamente, a cirurgia era considerada o último recurso aplicável a doentes para os quais não havia mais remédios que restabelecessem a normalidade. Durante séculos, esta modalidade de tratamento limitava-se à tentativa de salvar feridos de guerras e raríssimas operações eram bem sucedidas, sendo praticadas como magia ou por imperiosa necessidade por cirurgiões barbeiros. A retirada de cálculos da bexiga foi uma das primeiras operações realizadas, com 50% de mortalidade.
Shrove, by Sam Decker
24 bit / 44k There is a misconception that freely played music must be melee, a literal free for all. Of course, that needn’t be the case as there are ways to direct improvisers with clear intent. It also helps to build trusting relationships with those recruited to perform the music in such a communal spirit. Saxophonist/composer Sam Decker has focused much of his energy into purely improvised music.
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