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Andrea Barabino on Muck Rack

Andrea Barabino

As seen in: Nature, BioRxiv
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Articles

Sub-retinal transplantation of human iPSC-derived retinal sheets: A promising approach for the treatment of macular degeneration

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By Andrea Barabino, Rimi Hamam, Katia Mellal, Anna Polosa
| BioRxiv
Abstract Retinal degenerative diseases affect millions of people worldwide, and legal blindness is generally associated with the loss of cone photoreceptors located in the retina's central region called the macula. Currently, there is no treatment to replace the macula. Addressing this unmet need, we employed control isogenic and hypoimmunogenic induced pluripotent stem cell (iPSC) lines to generate spontaneously polarized retinal sheets (RSs).
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G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer’s disease

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By Anthony Flamier, Andrea Barabino, Gilbert Bernier
| Nature Verified
Abstract DNA sequences containing consecutive guanines organized in 4-interspaced tandem repeats can form stable single-stranded secondary structures, called G-quadruplexes (G4). Herein, we report that the Polycomb group protein BMI1 is enriched at heterochromatin regions containing putative G4 DNA sequences, and that G4 structures accumulate in cells with reduced BMI1 expression and/or relaxed chromatin, including sporadic Alzheimer’s disease (AD) neurons.
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Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme

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By Anthony Flamier, Mohamed Abdouh, Andrea Barabino, Rimi Hamam
| Nature Verified
Abstract Glioblastoma multiforme (GBM) is an incurable primary brain tumor containing a sub-population of cancer stem cells (CSCs). Polycomb Repressive Complex (PRC) proteins BMI1 and EZH2 are enriched in CSCs, promoting clonogenic growth and resistance to genotoxic therapies.
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