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Andrea de Bartolomeis on Muck Rack

Andrea de Bartolomeis

As seen in: Nature, MDPI, JAMA Psychiatry, Psiquiatria.com
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Articles

Neurometabolites and Antipsychotic Response in Psychosis : A Mega-Analysis

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By Bridget King, Kirsten Borup Bojesen, Charlotte M. Crisp, Andrea de Bartolomeis, Lieuwe de Haan, Kara Dempster, Richard Drake, Bjørn H. Ebdrup, Lejia Fan, Ariel Graff-Guerrero, Birte Glenthøj, Shiori Honda, Oliver Howes, René S. Kahn, James MacCabe, Marta Matrone, Kate Merritt, Philip M. McGuire, Shinichiro Nakajima, Stephen M Lawrie, Lena Palaniyappan, Francisco Reyes-Madrigal, Bruce Russell, Akira Sawa, Sukhi S Shergill, Krish Singh, Iris Sommer, James Stone, Junyu Sun, Sakiko Tsugawa, Fumihiko Ueno, Marieke van der Pluijm, James Walters, Kun Yang, Matthew J Kempton, Alice Egerton, Camilo de la Fuente-Sandoval, Li-Chung Huang, Meghan McIlwain, Elsmarieke van de Giessen
| JAMA Psychiatry Verified
Neurometabolites and Antipsychotic Response in Psychosis: A Mega-Analysis Key Points Question Do neurometabolite levels differ according to antipsychotic response in psychosis? Findings This mega-analysis of individual-level data in 1189 participants found elevated medial frontal glutamate, choline, and myo-inositol in individuals showing antipsychotic nonresponse compared to antipsychotic responders and healthy control individuals.
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Blood levels of D-aspartate oxidase, D-amino acid oxidase, serine racemase, and pLG72 are influenced by diagnoses of schizophrenia and autism spectrum disorder

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By Elisa Maffioli, Francesco Errico, Zoraide Motta, Raffaella di Vito, Joshua Grana, Elisa De Grandis, Claudio Bruno, Maria Riccio, Felice Iasevoli, Michele Di Maio, Tommaso Nuzzo, Carmela Bravaccio, Monica Gelzo, Giuseppe Castaldo, Andrea de Bartolomeis, Armando Negri, Loredano Pollegioni, Gabriella Tedeschi, Alessandro Usiello, Silvia Boeri, Sveva Bagnasco
| Nature Verified
Abstract Free D-serine (D-Ser) and D-aspartate (D-Asp) are increasingly recognized as key modulators of glutamatergic NMDA receptor-dependent neurotransmission, whose dysfunction has been implicated in neuropsychiatric conditions, including schizophrenia (SCZ) and autism spectrum disorder (ASD).
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Post-mortem brain analysis reveals altered monoaminergic system in the dorsolateral prefrontal cortex and hippocampus in chronic schizophrenia - Schizophrenia

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By Giuseppe De Simone, Antonio Rampino, Andrea de Bartolomeis
| Nature Verified
Abstract Schizophrenia is a multifactorial psychiatric disorder in which monoaminergic neurotransmission, particularly dopamine (DA), serotonin (5-HT), and norepinephrine (NE), is implicated in both pathophysiology and response to treatments. However, the regional composition and functional interaction among these neurotransmitters and their catabolites remain unclear.
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