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Andrea Lessa Benedet

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Articles

Plasma GFAP in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study

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By Antoinette O'Connor, Emily Abel, Andrea Lessa Benedet, Teresa Poole
| bmj.com
alzheimer's disease neurochemistry Introduction Glial fibrillar acidic protein (GFAP), a marker of astroglia activation, has been proposed as a biomarker of Alzheimer’s disease (AD).1 GFAP expression correlates with Aβ plaque density and cerebrospinal fluid (CSF) concentration is elevated in symptomatic disease.1 2 Ultrasensitive assays that reliably measure plasma GFAP show increases in AD that are relatively greater than in CSF.1 Autosomal dominantly inherited familial AD (FAD) is a...
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