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Articles by Andreas Beilhack
A simple and broadly applicable nanobody-based approach to generate potent TNFR agonists
Abstract The receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) are of overwhelming scientific and clinical relevance and stand at the center of intensive basic and translational research efforts. TNFRSF receptors (TNFRs) are engaged by membrane-bound ligands of the TNF superfamily (TNFSF) and, in some cases, by soluble ligand molecules released from the membrane-bound TNFSF ligand (TNFL) molecules.
Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease - Nature Communications
Abstract Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice.
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment - Nature Communications
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Proteins and antibodies HIS-tagged recombinant human Growth and Differentiation Factor-15 was produced in HEK293T cells (Invigate GmbH, Jena). The anti-human GDF-15 antibody used in this manuscript was generated in female C57BL/6J GDF-15-/–mice kindly provided by Dr. Jens Strelau (Heidelberg, Germany) and validated for binding affinity by surface plasmon resonance at NMI (Reutlingen, Germany). Specificity was tested by tissue cross-reactivity studies.
By Carmen Reitinger, Kilian Wistuba-Hamprecht, Hubert Hackl, Hemant R. Joshi, Phil Cheng, Mitchell Levesque, Matthias Goebeler, Markus Sauer, Falk Nimmerjahn, Stefanie von Felten, Michel Mittelbronn, Andreas Beilhack, Reinhard Dummer, Markus Haake, Lena Sorger, Jacob Späth, Rudi Beschorner, Alexander Thiem, Manfred Rüdiger
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Nature
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Novel pre-clinical mouse models for chronic Graft-versus-Host Disease
Lydia Verlaat, Katarina Riesner, Martina Kalupa, Beate Jung, Sarah Mertlitz, Constanze Schwarz, Jörg Mengwasser, Claudine Fricke and Olaf Penack* Department of Hematology, Oncology and Tumorimmunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany Despite considerable progress in allogeneic hematopoietic cell transplantation (allo-HCT) has been achieved over the past years, chronic Graft-versus-Host...
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