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Articles by Andreas Ranft
Comprehensive profiling of brain dynamics during anesthesia across phylogeny
Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, zebrafish and nematode. Applying massive feature extraction, we characterize local neural dynamics across >6,000 time-series features.
Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains - Nature Human Behaviour
Abstract The mammalian brain orchestrates the processing and integration of information to guide behaviour. Here, to characterize mammalian information-processing architecture, we combine functional neuroimaging and anaesthesia in humans, macaques, marmosets and mice. We show that breakdown of information integration is a convergent effect of diverse anaesthetics across mammalian species. As the system disintegrates, brain dynamics become more difficult to control.
General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species - Nature Human Behaviour
Abstract The human brain is characterized by idiosyncratic patterns of spontaneous thought, rendering each brain uniquely identifiable from its neural activity. However, deep general anaesthesia suppresses subjective experience. Does it also suppress what makes each brain unique?
General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species
Abstract The human brain is characterised by idiosyncratic patterns of spontaneous thought, rendering each brain uniquely identifiable from its neural activity. However, deep general anaesthesia suppresses subjective experience. Does it also suppress what makes each brain unique?
Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients
Unlabelled Box Evidence before this study One third of EwS patients with localised disease experiences relapse during follow-up. So far, no study has succeeded in identifying a broadly available bona fide stratification biomarker to predict which patients will develop EwS recurrence. SOX2 was studied in EwS by two different groups and linked to stemness and tumourigenicity in in vitro and in vivo models.
SOX2 expression identifies Ewing sarcoma patients with high risk for tumor relapse and poor survival
New Results View ORCID ProfileGiuseppina Sannino, View ORCID ProfileAruna Marchetto, View ORCID ProfileAndreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M Kiran, View ORCID ProfileTilman L. B. Hoelting, View ORCID ProfileJulian Musa, View ORCID ProfileLaura Romero-Perez, View ORCID ProfileFlorencia Cidre-Aranaz, View ORCID ProfileMaximilian M. L.
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