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Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma
Open AccessArticle by Sebastian Fuest 1,†, Christoph Post 1,†, Sebastian T.
Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients
Unlabelled Box Evidence before this study One third of EwS patients with localised disease experiences relapse during follow-up. So far, no study has succeeded in identifying a broadly available bona fide stratification biomarker to predict which patients will develop EwS recurrence. SOX2 was studied in EwS by two different groups and linked to stemness and tumourigenicity in in vitro and in vivo models.
SOX2 expression identifies Ewing sarcoma patients with high risk for tumor relapse and poor survival
New Results View ORCID ProfileGiuseppina Sannino, View ORCID ProfileAruna Marchetto, View ORCID ProfileAndreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M Kiran, View ORCID ProfileTilman L. B. Hoelting, View ORCID ProfileJulian Musa, View ORCID ProfileLaura Romero-Perez, View ORCID ProfileFlorencia Cidre-Aranaz, View ORCID ProfileMaximilian M. L.
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