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Safety and activity of RO7300490, a bispecific CD40 agonist targeted to fibroblast activation protein, in patients with advanced solid tumors: a single-arm, multicenter, first-in-human, phase 1 trial

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By Ignacio Melero, Alexandra Epp, Nicole A. Kratochwil, Chun Lin Wu, Michael Hettich, Natascha Rieder, Petra C. Schwalie, Solveig Badillo, Nadine Kumpesa, Andreas Thommen, Danielle J. Vugts, Victor Moreno, Eduardo Álvarez Verified, Carlos de Andrea, Iben Spanggaard, Dae Ho Lee, James B. Spicer, Fiona Thistlethwaite, Do-Youn Oh, Antoine Hollebecque, Stefan N. Symeonides, Bernhard Reis, Corinne Rusterholz, Georgios Kazantzidis, Julia Lostes Bardaji, Olivera Cirovic
| Nature Verified
Abstract CD40 activation on dendritic cells (DCs) enhances tumor antigen cross-priming of tumor-specific cytotoxic T lymphocytes, strengthening anticancer immune responses. RO7300490 is a fibroblast activation protein (FAP)-targeted CD40 agonist antibody. In this phase I study, 80 patients with advanced and/or metastatic solid tumors received RO7300490 biweekly (dose range 16–1,100 mg). The primary objective was to evaluate safety and tolerability.
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