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The Association of Neonatal Respiratory Distress With Ciliary Ultrastructure and Genotype in Primary Ciliary Dyskinesia
1 Introduction Primary ciliary dyskinesia (PCD) is a rare genetic disorder of motile cilia resulting in chronic oto-sino-pulmonary disease, organ laterality defects, and infertility [1]. Neonatal respiratory distress (NRD) is a common early manifestation, occurring in approximately 80% of people with PCD [1-3]. Affected neonates present with tachypnea and hypoxemia in the first days of life and often require supplemental oxygen for several days to weeks [3, 4].
Pediatric Pulmonology 2024 Year in Review: Rare and Diffuse Lung Disease
1 Introduction In the past year, significant progress has been made in our understanding of fields including children's interstitial and diffuse lung disease (chILD), non-cystic fibrosis (CF) bronchiectasis, and pulmonary complications of childhood cancer. Our research and clinical communities continue to recognize the importance of collaboration to advance our understanding of these conditions and improve patient care.
Pediatric Pulmonology 2023 year in review: Rare and diffuse lung disease
1 CHILD An important aspect of children's interstitial lung disease (chILD) is clear and concise classification of the diseases that enhance provider education and diagnostic abilities. Nathan et al.1 describe the European approach to diagnosing chILD, including descriptions of the most likely disease based on clinical histories, histopathology findings, radiographic findings, bronchoalveolar lavage results, genetic testing, and other “biological investigations” (i.e., lab testing).
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