Andrew Beggs on Muck Rack

Andrew Beggs

Birmingham, Royal Leamington Spa
As seen in: Color Research & Application, Nature, Frontiers, MDPI, Genome Medicine, The Journal of Immunology, TechTrends
Prof Cancer Genetics & Surgery @unibirmingham, Colorectal Surgeon @uhbtrust, Scientist as well as surgeon. MRC Senior Fellow. Cancer/Surgery/Genomics.
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Articles

Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting - Nature Communications

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By George E. Ronson, Katarzyna Starowicz, Elizabeth Anthony, Alexander Garvin, Andrew Beggs, Matthew J. Edmonds
| Nature Verified
Abstract A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however, the mechanistic basis of these observations are unclear. Here we reveal two distinct mechanisms of Polθ synthetic lethality, identifying dual influences of 1) whether Polθ is lost or inhibited, and 2) the underlying susceptible genotype.
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Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism - Nature Structural & Molecular Biology

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By Yavor Hadzhiev, Andrew Beggs, Joseph W. Wragg
| Nature Verified
Abstract Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, little is known about the role of the core promoter in defining transcript identity and post-transcriptional fates, a potentially crucial layer of transcriptional regulation in cancer.
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Tumour immune microenvironment prognostic factors in locally advanced rectal cancer, a systematic review

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By Rebecca Lefroy, Malcolm J Price, David McArthur, Andrew Beggs, Alasdair Ball
| Frontiers
1Institute for Biomedical Research, Department of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom 2Department of Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom 3Department of Surgery, The Shrewsbury and Telford Hospital NHS Trust, Shrewsbury, United Kingdom 4Institute of Applied Health Research, Department of Applied Health Sciences, University of Birmingham, Birmingham, United Kingdom Introduction: Understanding...
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