Andrew Knox

Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article. Supporting Information Filename Description cmdc70170-sup-0001-SuppData-S1.pdf14.5 MB Supplementary Material References 1, , , , , , Science 1946, 103, 59. 2, , , J. Am. Chem. Soc. 1947, 69, 1837. 3, , , J. Am. Chem. Soc. 1948, 70, 2091. 4, , , J. Am. Chem. Soc. 1948, 70, 1765. 5, , , J. Am. Chem. Soc.

Introduction Epilepsy is a common childhood disorder, and one third of children with epilepsy have lower quality of life due to drug-resistant seizures.1, 2 Greater availability of clinical genetic testing has the potential to reduce the prevalence of drug-resistant epilepsy by guiding more precise therapy.