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Highlights • HAT1 is an EGF-stimulated acetyltransferase required for EGF-dependent growth • HAT1 holoenzyme specifically binds to histone H4 promoters • Histone H4 promoters contain an acetate-sensitive genomic element • HAT1 expression is associated with poor cancer outcomes in humans and mice Summary The energetic costs of duplicating chromatin are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs.
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