Andrew Marcel Pregnall on Muck Rack

Andrew Marcel Pregnall

As seen in: Nature
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Articles

A redefined InDel taxonomy provides insights into mutational signatures - Nature Genetics

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By Arjun Nanda, Giuseppe Rinaldi, Andrea Degasperi, Cherif Badja, Andrew Marcel Pregnall, Laura Heskin, Joao Dias, Matthew Brown Verified, Helen Davies
| Nature Verified
Abstract Despite their deleterious effects, small insertions and deletions (InDels) have received far less attention than substitutions. Here we generated isogenic CRISPR-edited human cellular models of postreplicative repair dysfunction (PRRd), including individual and combined gene edits of DNA mismatch repair (MMR) and replicative polymerases (Pol ε and Pol δ). Unique, diverse InDel mutational footprints were revealed.
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The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells - Nature Genetics

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By Cherif Badja, Ilias Georgakopoulos-Soares, Salome Jingchen Zhao, Andrew Marcel Pregnall, Firas Sadiyah
| Nature Verified
Abstract The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2- and PALB2-mutated cancers. It is under investigation in phase I and II trials.
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