Department of Anaesthesia, Manchester Royal Infirmary, Manchester, UK This editorial accompanies articles by Dias et al., Anaesthesia 2026; 81: 222–31 and Elhadjene et al., Anaesthesia 2026; 81: 434–5. Parkes, A. (2026), Peri-operative allergy: continuing to navigate uncertainty. Anaesthesia. https://doi.org/10.1111/anae.70243 References 1, , , et al.