Andrew Shiau

Editor’s summary Massive genome rearrangements, or chromoanagenesis, are common in cancer and associated with poor prognosis. The most frequent form, chromothripsis, arises when one or more missegregated chromosomes form micronuclei that rupture, exposing their chromatin to the cytoplasm. Using an imaging-based small interfering RNA screen of human nucleases, Krupina et al.