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Articles

Identification of pathological CD133+ endothelial cells in venous malformations

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By Noa Shapiro-Franklin, Shirley Yang, Michael J. Schonning, Andrew Zeiler, Seung Koh, Anna Alkelai, June K. Wu, Carrie J. Shawber, Averill Clapp, Mason G. Harvill, Emma Iaconetti, Meghan Perez
| Frontiers
Abstract Introduction: Venous malformations (VMs) are congenital malformations of the venous system. Histologically, they are composed of dilated vascular channels. Prior studies have demonstrated that CD31 + endothelial cells (ECs) in VMs have pathogenic variants. Recent studies by our group found that the EC progenitor marker, CD133+, was expressed on VM endothelium in patient tissues. We hypothesized that a CD133+ VM endothelial cells contributes to VM pathobiology.
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