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Andrey V. Kajava on Muck Rack

Andrey V. Kajava

As seen in: Nature, BioRxiv
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Articles

Quantitative model and physical mechanisms of iRBC membrane curling during egress of malaria parasites

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By Andrey V. Kajava, Gorkavyi Nick, Andrea Parmeggiani
| BioRxiv
Abstract Egress of malaria merozoites from infected red blood cells (iRBC) is a critical step in the parasite life cycle. The egress is accompanied by the formation of a pore in the erythrocyte membrane, followed by an outward curling of the membrane around the pore, resulting in a complete eversion of the erythrocyte membrane, pushing the parasites away.
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Developing machine-learning-based amyloid predictors with Cross-Beta DB

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By Michael Dunne, Javier Caceres-Delpiano, Andrey V. Kajava, Valentin Gonay
| BioRxiv
Abstract Due to shifts in environmental conditions, mutations, or interactions with other biomolecules, some proteins that would normally be soluble can undergo aggregation, resulting in the formation of clumps of amyloid fibrils. Understanding of this phenomenon is of paramount importance due not only to its association with various diseases (including Alzheimer's disease), but also due to increasingly abundant evidence for its functional roles.
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Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo - Molecular Psychiatry

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By Fleur Vansenne, Andrey V. Kajava, Anne Debant
| Nature Verified
Abstract The RhoGEF TRIO is known to play a major role in neuronal development by controlling actin cytoskeleton remodeling, primarily through the activation of the RAC1 GTPase. Numerous de novo mutations in the TRIO gene have been identified in individuals with neurodevelopmental disorders (NDDs).
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